THE FLIP SIDE with Andy Mai
TFS#90 - Jacob George On Drug Research & Development, Hepatitis Cures, Blue Zone Diet w/ Renowned Hepatologist & Liver Research Scientist Prof.
Professor Jacob George is a renowned hepatologist and liver research scientist who studies the causes of and mechanisms for the development of liver disease and liver cancer.
Professor George’s work has made significant contributions to clinical practice. His team first identified the role of interferon lambda 3 gene polymorphisms for predicting treatment response in chronic hepatitis C, and a second gene polymorphism that interacts with interferon lambda 3. These discoveries are considered major advances in the field and the finest examples of ‘personalized medicine'.
Professor George was an author of the groundbreaking study of combination telaprevir, pegylated interferon, and ribavirin therapy for hepatitis C, which changed the landscape of hepatitis C treatments, heralding the era of direct-acting antivirals. His work identifying insulin resistance as the universal underlying pathophysiological abnormality in fatty liver disease underpins the majority of research on this condition and is the cornerstone of current therapy (lifestyle intervention; exercise; insulin-sensitizing agents). He also first described the association between hepatitis C and insulin resistance.
Professor George is an advisor to Hepatitis Australia, the Transfusion Related AIDS and Infectious Diseases Service, and at state and national levels, on viral hepatitis. He oversees research for the Asian Pacific Association for the Study of Liver. He is a Fellow of the American Association for the Study of Liver Disease.
Professor Jacob George MBBS, FRACP, Ph.D., FAASLD
CHAPTERS:
00:00 Intro
00:20 Meet Prof. Jacob George
01:00 Professors In The Hospital
02:30 KPIs For Delivering Clinical Care
03:40 Research & Academic KPIs
05:00 Medical Research Method
06:10 Mice Lab Testing
08:30 How Washing Hands Saved Lives
09:40 Pathophysiology Cycle
11:40 Curing Hepatitis C
12:30 Designing Drugs
14:40 Growing Virus In The Lab
16:00 Hepatitis B Breakthroughs
18:40 Virus Reservoir Forms
20:40 Eliminating Dormant Virus
22:00 Early Phase Human Studies
24:30 Long Term Side Effects
24:50 Thalidomide Scandal
26:00 Clinical Trials
27:00 Post Marketing Research
29:05 Cost vs Benefit
29:45 Independent Experts
31:55 The Covid Vaccines
33:15 Do Masks Work?
35:30 Does Vaccine Works?
37:20 Personal Risk Factors
37:55 The Old Man’s Friend
39:05 The Immune Response
41:30 The Immune System
43:05 Natural Immunity
44:30 Immune System Memory
46:15 Average Human Lifespan
47:00 Healthy Aging
48:20 Cancer Development
50:50 The Blue Zone Diet
53:35 Social Constructs On Food Behavior
55:20 The Agricultural Age
57:30 Nutritional Ecology
59:25 Child Rearing Experiment
01:02:15 Knowledge Dissemination
01:04:10 Just A Speck
01:04:35 Outro
- Broadcast on:
- 19 Jul 2022
Professor Jacob George is a renowned hepatologist and liver research scientist who studies the causes of and mechanisms for the development of liver disease and liver cancer.
Professor George’s work has made significant contributions to clinical practice. His team first identified the role of interferon lambda 3 gene polymorphisms for predicting treatment response in chronic hepatitis C, and a second gene polymorphism that interacts with interferon lambda 3. These discoveries are considered major advances in the field and the finest examples of ‘personalized medicine'.
Professor George was an author of the groundbreaking study of combination telaprevir, pegylated interferon, and ribavirin therapy for hepatitis C, which changed the landscape of hepatitis C treatments, heralding the era of direct-acting antivirals. His work identifying insulin resistance as the universal underlying pathophysiological abnormality in fatty liver disease underpins the majority of research on this condition and is the cornerstone of current therapy (lifestyle intervention; exercise; insulin-sensitizing agents). He also first described the association between hepatitis C and insulin resistance.
Professor George is an advisor to Hepatitis Australia, the Transfusion Related AIDS and Infectious Diseases Service, and at state and national levels, on viral hepatitis. He oversees research for the Asian Pacific Association for the Study of Liver. He is a Fellow of the American Association for the Study of Liver Disease.
Professor Jacob George MBBS, FRACP, Ph.D., FAASLD
CHAPTERS:
00:00 Intro
00:20 Meet Prof. Jacob George
01:00 Professors In The Hospital
02:30 KPIs For Delivering Clinical Care
03:40 Research & Academic KPIs
05:00 Medical Research Method
06:10 Mice Lab Testing
08:30 How Washing Hands Saved Lives
09:40 Pathophysiology Cycle
11:40 Curing Hepatitis C
12:30 Designing Drugs
14:40 Growing Virus In The Lab
16:00 Hepatitis B Breakthroughs
18:40 Virus Reservoir Forms
20:40 Eliminating Dormant Virus
22:00 Early Phase Human Studies
24:30 Long Term Side Effects
24:50 Thalidomide Scandal
26:00 Clinical Trials
27:00 Post Marketing Research
29:05 Cost vs Benefit
29:45 Independent Experts
31:55 The Covid Vaccines
33:15 Do Masks Work?
35:30 Does Vaccine Works?
37:20 Personal Risk Factors
37:55 The Old Man’s Friend
39:05 The Immune Response
41:30 The Immune System
43:05 Natural Immunity
44:30 Immune System Memory
46:15 Average Human Lifespan
47:00 Healthy Aging
48:20 Cancer Development
50:50 The Blue Zone Diet
53:35 Social Constructs On Food Behavior
55:20 The Agricultural Age
57:30 Nutritional Ecology
59:25 Child Rearing Experiment
01:02:15 Knowledge Dissemination
01:04:10 Just A Speck
01:04:35 Outro