Hey folks, nothing beats steak itself, but if you're ever in a rush with no time to cook, want easy nutrition after workout or need to give your protein and take a quick boost, then I'd strongly recommend you look at Equips grass fed beef protein. Unflavored prime is just one ingredient. Grass fed beef is isolate. Just one scoop is equal to four ounces of grass fed beef. There are no fillers, junk, artificial ingredients, glyphosate, or heavy metals. Use code Sean Baker 20 to save 20% your first order on equipfoods.com. I had cancer 21. No amount of droves got me well, so I finally experimented with diets and alternatives, and that's when I became interested in genetic background. I was able to actually design a personalized program for myself, where I'm now in my 16th. I'm more vital and healthy than ever. No, no, they're approximately 8% of cancers due to lifestyle prevention. Environmental causes as opposed to 20% of the genetic if you're critiquing in the standard American diet, the sad diet, right? Your genes are going to tell you how quickly you're going to get diabetes. Our DNA informs how the body naturally operates, and with that awareness, we can then tailor our goals to tailor how we go about achieve our goals to that. I'd rather live to 90 with a solid brain and then just not wake up, than I would 120, giving a lot. Just I guess by way of introduction, if you guys are something I'd maybe just quick-minute to touch and toss your background. I know the stuff you have in the background in pharmacy initially, and I guess we have some more for you to share this year. If you guys take a second to share who you are, your background, and we'll be able to look at your description. Okay, so I have a Dr. Dubriam Thomasi, award certification in clinical nutrition, and I had cancer 21. No amount of drugs got me well. So I finally experimented with diets and alternatives, and that's when I became interested in genetic background, because I have a very compromised genetic background. Not only am I a celiacs, not only am I lactose intolerant, but then I process some of my vitamins, finding out this, and how my body can heal, even though it has his deficits, NTHFR, etc. I was able to actually design a personalized program for myself, where I'm now in my sixteenths, I'm more vital and healthy than ever, and then I turned that into a practice to a wishing you wellness, which was helping others find their path through all of the information that's out there. Okay. Hey, Chris, Chris, did you want to share your background as well? Absolutely. My background originally was in computer science. I studied artificial systems. I was very fortunate. I got several grants since I spent several summers in the lab, being a true hardware nerd, and that's where I realized I didn't want to be a land-based nerd. I wanted to live with people, and so initially I worked in the corporate sector. I did a lot of organizational management with how I'd interface with technology, but again, it wasn't deep enough into the body, and so I went back to school for naturopathy. A lot of people are confused by that, but I think that naturopathy endeavors to understand root cause of disease through systems, and that is exactly what computer science is, right, as study of systems and how they work. I switched silicone for carbon-based systems, and worked as a naturopath with a lot of focus and integrative medicine. In my first four years of practice, we're an integrated clinic, right, worked alongside an MD, and we looked at both what was illness present and then how we prevent it in the future. When COVID happened, a lot of time, my hands, and I picked up genetics. I was introduced to the DNA company because I had such a corporate background, and so during that time, not only did I get to sit and play with much of genetics and how that can be applied to clinical practice, right, to species, age, root cause of disease. I also got the opportunity to play around with our algorithms and look at how we leverage speaking of physiology to make functional genetics more accessible to practitioners, because I find right now the biggest hurdle for adoption of genetics within clinical practice, especially the doctors, is they don't necessarily have the time to learn it. This is how we leverage technology to support that so that people can use this. There's a lot of potential in genes in health. Thanks, Lu Chan. This is the origin of, I guess you said, the DNA company, which is a functional genetic functional, as well, which some of all those lies. I guess the assumption is that here are things that impact this environment, what we need to impact is cooling, subdue to a million factality differentially, and considering that, I don't know about can map. I mean, I can't imagine that if we look at some of the same western nights, and it's good for in, but regardless of what your genetic background is, this is a common style. But how do you go from that sort of broad base, say, nobody should be sucking down this 48 ounce of Coca-Cola or the I think that's cool, and I'm like, anyway, I could screw that up for what you're doing at background is something more nuanced to say, maybe this thing is better for you. How did that, is that right? Am I on the right track and thinking about this, how does that evolve that maybe you could find a white somewhere up inside into that, because there's some more, you know, and it's some genes that are all different and all to say what that is. As you mentioned, there's many steps and things like that, so maybe you can get a spare point on that fucking guess. Yeah, Dr. Stuff will allow me to go take the amount of this one. I think one of the more popular is information around genetics and health is around cancer. You know now that approximately 8% of cancer is due to lifestyle management. Environmental causes as opposed to 20% say of genetics, and so when we can translate that into diet, and a lot of people come to me and say, hey, but as my genome tells me I'm going to get diabetes, because it tells me I'm going to struggle with this cardiovascular condition. And the answer is not necessarily, but it sets the stage, right? So for example, with diabetes, which is we know some diet based, if you were, you can have certain genes, certain meals that will be supposed to be towards risk of diabetes, that is that inevitable? Absolutely not. You can leverage diet to avoid that. That's that if you're critiquing in the standard American diet, the sad diet, right? Your genes are going to tell you how quickly you're going to get diabetes. Anyone on that standard American diet eventually will end up with metabolic disorder, diabetes, cholesterol, etc. Genes will dictate how quickly that comes to be, and to an extent how painful, right? Our genes really will carry the rate of inflation relative to those factors, the rate of insulin resistance relative to those types of other things relative to what we're fueling are genes in our body with. Last night's check, I suspect technology and change this, but I can't change my genetic code, right? I was going to sit and sit and work, and I know which people are talking about, telling the word of our villain, ring light melody in fact, that layer, which may be horrifying, or maybe bits that went on to kind of question that, but so what does that mean? Like what you mentioned, but your genes may predict how long it takes you to get diabetes. They're exposed to this noxious food or whatever it might be. So how does that work in practicality? Would it be that, let's just say, I think maybe I can get away with even when I'm still on 50, or somebody else goes to important thought. How do we use that information to come on the same sort of actual role to actually play it? Yeah, I'll start in the maybe Dr. Staff, I think he's so much experienced in this space. I love you too, and to follow up. But I think people approach me and they're asking for support in their health. They're coming from one of two places. There's this problem, and I want to understand how to solve the problem, or I'm seeking to live forever, right? I really want to live well, and I think genes can offer insight into both spaces, right? If there's a problem, we can look into what genes are associated with that, and how do we tailor our plan specific to what your genes say, and how we go about that, right? And I think especially when we're diet, there's a lot to be said there with what genes lend to an easy addition, an optimal adoption versus not. And then I think when we ask the larger question along the identity and living well, not just living for the sake of being healthy, but actually happy and healthy and enjoying the health that you have. Genes are foundational in understanding where the disabilities of the body are, so that instead of this raw rest show that I must do everything to be healthy, you can focus that energy and effort into what your life's disabilities are, as opposed to trying to do everything so that you can invest energy in the happy stuff, right? Not just health, what health so that we can live happily, not so that we're always just trying to be healthy, helping sons. And we do stuff if you want to follow up with where we want to example here, we're quite pleased with that. Well, I think one of the things that people say is what not only does right tell me, is it the carnivore diet, is it the keto diet, is it the vegan diet? My family's always had XYZ problems. My family has heart problems. I think the difference between what the DNA company offers versus other companies, some people will just say, you shouldn't eat fat, you should just take your lighter lens, whatever. They do a very a small amount of general overview. The difference with the DNA company is we have 73 actionable genes. So as you say, I have an issue digesting dairy, then we look at that gene that is dairy, and we look at how do you represent that and can you digest or do you have the enzymes to digest? Do you not? And then when somebody's doing the carnivore diet says, can I add a little cheese or not? Okay, your genes say X, which means you are more likely to, which means if you're going to have that you can only have a firm cheese, like for Parmesan, not a soft cheese and not a fiesta lens from someplace. And it's so in your highest and greatest good, that would be a no. When somebody has empiric evidence of mind genes lay out, whether it's cardiovascular inflammation, whether it is your D vitamin, can I do a D2, which isn't an active D? No, I don't have the enzymes converted or the NWU. I've got to use a D3. And I don't want to have the extra calcium around so that if you use a D3 with K2, you can give them your genes lay out. This is your blueprint. Why would you buck your blueprint? You don't build a house and say, here's my blueprint. I'm going to do something else. You say, here's my blueprint. And when I follow it, I build the strongest house. And so it allows people to really have information to customize for them, how much do I do? What can I do? What is my tendency? And then they can see before and after with their results. So I would, let me just, so I see people that at some point, I've seen this people in a quantum system, that like significant allergies to shellfish. And they do, for some reason, they will die. And then a year later, for some reason, they try shellfish. I'm like, I don't have to try it. They do. They say, I'm no longer reacting to this. Is that genetic? Is it epigenetic modifications in a curve? Because obviously we even know that there's these different things that can in fact, our genes are expressed as a genotype of phenotype. And so how does that play a role? Because you've got, you've got the blueprint. This is a base pattern, but you can modify that in some way, based on the bulk of it's, even if it's very complicated. There's, you know, all these same gene logos and inhibitors and so on and so on. How does that aspect of the blade? Because you say, hey, I don't produce lactase. I can never have milk for us in my life. Or how do we, is there some level of mutable or plasticity to our genetic expression? I would not for us. I would not for it. It's probably emerging from a few different systems, right? I think to your point, you raise the idea of epigenetics, right? So in this idea that you can think of the genome, like the score of music, right? You look at a page, there's no tone of page. And if you look at that by itself, you can play it away. But the power and the blades of having a conductor come in, as they notate, they direct differently. And that's the same concept of epigenetics, in the sense that your genes are this beautiful outlay of how the body should work, and then diet, et cetera, nutrition, stress, whatnot, will come in and notate that. And so what's happening with that shift in diet, with that shift of hey, let's do just meet for a year, you're changing the way you play that music. And so you hear it differently, it's expressed differently. So I think that's one mechanism that epigenetic, you're changing how much, how often those genes are expressed. But separate to that, you've also just said for a year, it does look a little different within the space with my GI, and you've influenced the microbiome. And I'd be curious if this person had an allergy test before and after, if it was a true allergy or more, it was like a microbiome gut sensitivity to, because I think those are two different questions. And I think diet, in particular, a year-long regime of whatever it might be, will shift both elements. It will shift what genes are being expressed, how they're being expressed, so that along with enzymes, that includes higher details and that important production even. And I'm completely separate to that. It's how is the biome being expressed, which in turn will also influence genes. I think this again is that concept of it's not one thing it's many things, and that's the emergence thereof. So, I know it's going to say, leaky gut, when you pull out an agent, such as in many cases, fighting gases, mutant lectins, it allows the gut to repair who have rested the gut. And so, as it repairs, and maybe we start getting some more butyrate in there and the gut tissue, because we close the tissue, repairs so quickly, all of a sudden, they have an offending agent. Now, do they still have a sensitivity? They may. They may have a sensitivity, but it doesn't express, because at least not on an acute level, it may on a low rate level, but they're not seeing that. They know last time I got a rash, last time I got a stomachache, I don't have that now. And so, there's benefit to allowing us to rest with a more simplified diet and taking offending agents out. Let me ask, because you mentioned there were 73 actionable genes that you guys involve yourself. How does your process run you off? So, you take a some sort of gene sample, cheeks, well, let's test out a long-term state. You figure out what people are dealing with, and then how do you... I guess maybe even more, if you talk on the whole channel, that's okay. Yeah, and so, it's so currently we take us to live with sample. We are shifting to the cheeks pump. It's a little more consumer friendly. So, from that, we take that sample back to my lab, and we analyze the genomic information there. And the litmus test is to what genes we care about, right? Because I think the genome budget was completed in what I did 20 years ago, by one of our foundational scientists within this. And I think following that, we expect to be like, oh, we're going to know all the secrets of human health, because we have all this data. And what did not happen was really actionable insight. We had all this data, and we got lost within it, most of it was noise. And so, the mission of functional genetics, and the mission of genetics, the rights, the epistemic years, is really what's useful, what is not noise, how can we apply this? And so, the litmus test for these 73 genes, and we're rolling out a new set soon, and in a few months, the litmus test really is, if I have one presentation, and Dr. Stuff has the exact opposite presentation, does that change the clinical care plan? For example, there are genes that will tell you how do you respond to stressful situations, right? And we need to know that I have one set and her and another, and we're both presented with the same stressful stimuli. These are behavioral power, and they're going to be different. Or if someone comes forward and says, hey, I'm really struggling with weight management, are there genes that would tell us how to manage that difference? We take that genetic information, we put it through our various algorithms, and sometimes we'll analyze genes as stand-alone, right? There's some that are really important, a way, for example, we know that will really influence how you metabolize your thoughts, and how that influences the altered dementia. But we'll also take a few in concert, in particular with my behavior, and this is very well that's a critical plan for minuscution. We look at several genes and different combinations there, and how that impacts how your brain and your body will process different emotional, stressful stimulants, stimulators, right? And how that can be leveraged to understand how you are, how you respond to the environment. So we're not looking at everything, right? A lot of companies that come in and say, we're going to analyze everything. To date that has a bill. We look at genes that if different, how does that tell us what to do as clinicians? Yeah, I remember the promise of encoding human genome was related to cancer and all these work, and obviously none of that has proven true if it was as input as a response. We talked a little bit about nutrition, selling the plant and asking about insults. What are the things that you can do tomorrow? Me, I like to look at sleep, exercise, health, and sanitary planning college. To me, it was a foundational thing. It's how new this person should be focusing on this type of exercise, this type of if we were held detailed in your sort of analysis of which you can ask it. Absolutely. The stuff we do like to kick this off, or shall I? Because you can go over it. Yeah. So let me leverage the example of exercise, because I think this one is interesting, right? And just like diet exercise, those three traumas, a lot for the 80s, where it was called cardiovascular and that begins this cross that not to be treating genes will set both hormone, like sex, steroid, or on profile, i.e. are you working towards lower metabolism last week, or muscle gain compared to the more apt towards that. And separate to that, they will also dictate recovery and the inflammatory burden that exercise can place in the system. So when someone comes in and says, what is the ideal exercise based on the genes? First of all, look at their cardiovascular system and how prone they are towards cardiovascular information, the more prone you are towards cardiovascular information, the more you should be sticking towards the resistant train, that which does not burden your entire cardiovascular system with low-grade information, right? And we know that exercise is going to create information, it's not a bad thing, that supports the generation muscle and how it confords all those positive benefits, but we don't want to be overflowing that cup, right? So those with more cardiovascular information, the bad thing, shifting towards weight resistant training. We then also look at recovery time. Do you and lately have those mechanisms that support recovery? Because the poorer you are in recovery at all, right? The more time that should be given between workouts so that you optimize and you capitalize. Now when you look at hormone profiles, that's a little bit of a humbler, but also a bit of the expectations that are. If you are someone who is naturally androgen-dominant, you are going to be that person that can just look at weights and you're going to gain muscle mass compared to a person who has more of an estrogen-dominant profile, they're the person that might clock an hour a day on the weights, but takes them two or three times as long to realize those benefits, right? So I'd offer exercises a beautiful example of we can gain different insights into how a body natural is, so that we can then focus our energies and efforts on the optimal goal that we're seeking. Be that and dress training, be that vascular training, be that whatever the person's goal that comes in, right? Our DNA informs how the body naturally operates and with that awareness, we can then tailor our goals, then tailor how we go about cheering our goals to that. And just to carry out with the goals, everyone's looked forever, right? Well, we've given our DNA, hopefully we're quality-line, but what are the... You say, these are short-term goals, and we can... Because anytime somebody promises me I'm going to live a long time, I just... I'm like, okay, whatever. I don't believe you because there's no proof. So how do you even assess someone's actually making progress, devoting a goal about more of the goals that we put them in, or lose weight, obviously, and step on a scale looking there on those types of things? So what are the type of goals that you ask for themselves? I think one of the things of the company really emphasizes is quality over quantity. Yes, there's the big thing I can live to be 100, 120, I can live... I can tell you I have folks in my late 80s right now that did all the opposite of what our DNA does. And they were in a very strict Western model, whereas my doctor knows best, and it ended up, come up by castrating my father, where she lay act. Still, we don't process dairy. He was a wheat farmer that then was a wheat milling grain engineer. So he was around wheat his whole life, but he always had digestive issues. So now at 88, she is having to undo all the cardiovascular meds and chronic inflammation, and he's at cancer, five times, high, different kinds of cancers, because he didn't understand the right foods in his body, the right environment for his body, the right detox for his body. So the company, as well as individuals, choose to have quality over 20. I'd rather live to 90 with a solid brain and then just not wake up. Then I would 120, giving a lot. When you optimize your systems, whether it's a car that's been preserved into 1957 Chevy or something, and now it's considered a special edition. And I think one of the things people are realizing is the old adage, and they weren't 40 years of their lives to get your retirement. And then they spent all the money they've accumulated to keep their health, because they've lost their health along the way, whether it's the way they live, whether it's what they ate, whether it's their stress. When you optimize your gene environment or your nutrient genomics, the foods, the supplementation should fit your blueprint, and then go, oh, I can have quality. I can be 60, and not have to be on any chronic meds. I can be 70, and maybe I take some hormone replacement, but I'm not on a cholesterol med and a diabetic med, and I don't treat every day. I think a lot of people who turn that low rate inflammation down, now we need some inflammation to this trailer's repair, but when you turn that inflammation down from I heard it a six or seven every day to, I wake up and I don't hurt. I can't exercise. I feel glad to get out of bed rather than I just want to put the colors back on my head. Those really are the things we hear in clinic where people went. Okay, maybe I'm still as a woman as size 12. I'd like to be at two like I was in high school, but my clothes fit better and I have energy, and I feel like going out there and not saying, and my kids say, Mom, it's nice to have you back because I had checked out of life. I was living that I was dead, and it's just so wonderful to have people really feel vital again and want to engage in whatever it is their passions are. I think a lot of things that are genetics in general, are you talking about personally with our own bodies? Well, I think maybe I've not just my genetics. I don't know why it's going to go on. I think fortunately, again, if the average person came in there, what would be something that would say, Hey, your genetics would show that this is a problem for you. And well, I guess maybe some things that affect us on a daily basis, we don't think about some of the genetic things. I'll tell you this is really a bad idea or this is what you should actually do, but wouldn't that would be not into it. Because like I said, I could say, eat, rice, eat. That's pretty, doesn't take a line inside the meat to top the meat and tap it. And you guys already think it's like, Hey, this is really a bad idea for you. I mean, one of the things that surprised me the most is most genetics are, okay, you can eat fat or you don't have the MTHFR or you've got biles next up. The things that set the DNA company for is we get into mood and behavior. And I'm a very selfish person. I'm a very get it done. I had a person, but I liked had two or three projects all going at once. And I'll be washing the dishes and I'll be got something on the computer that's updated and I'll be and I'll be running. And I didn't realize that in my genetic makeup, I actually have a very high propensity for ADHD, but I don't have ADHD. But I also can't really lose sense, but I go, okay, I don't really care. So what I've learned is I've learned how to systematically tie up those loose ends because they may not add her to me, but they not are to other people. And whether comes to your diet, and you go, I know I can't have gluten, I am strict on gluten and any cross contamination. But what I found out was also a lot of people think of empty. There's empty HFR. There's HMT. There's MTRR. There's MTR. There's a whole bunch of components, whether do I convert my home assisting to methyamine and lower inflammation, or do I keep it up? People think MTHFR speak the one and only. We go further and we have multiple. Do you convert? Do you have the enzyme activities? Are you able to reduce? We have, how would you react to statins? We have so much more that you can say, I would not go on a statin because I have, we understanding of how my body processes and that inflammation or cholesterol is not necessarily a bad thing, but a lot of the studies around cholesterol were flawed. Let me put my pharmaceutical background because I worked for pharma for 10 years realizing how many associations are paid off to come out of certain test results. I now have a data to say, okay, my genes lay out. Here are the things that I can systematically check to see I'm on track. I'm not worried if I have a 240 cholesterol. It doesn't have to be 120. The cardiologist might want that. And so you're able to put all those systems together. I encourage you to talk about I'm less impressed with a single number, but more of a trend saying with me, I want to see a trend that I want to look at how are you designed so we can make that trend in the right way. But there's a lot of practitioners out there that don't know that they're so bought into a system that they were trained in and they don't look at the whole organism and all the functions that lie into each other. The power of working with all those data sets and making a Venn diagram. Here's what my genetics say. Here's what my diet is. Here's what my lab looked like. There's how I steal. And then let's overlap them and see that ideal in the middle so that somebody really optimized. And the power of what we do is we get actionable. We can see before we can see after the power of what Romero is attempting to do is take people that are educated in that model and lay not just a single number and slap a stat in on you. And we also have PGX tests. And PGX tests say, how will your body process a stat? And if you and your practitioner decide that is the right course for you, maybe you're one that is set up horribly with APOE2 or with and you need a stat, which one is going to optimize? So we can layer extra data that a lot of people don't have. So you need to get the best result of that quality again. Yeah. Yeah, you discussed a little bit about that coming a little leaky doubt. Got microbiome. Are you guys involved in that as well? Are you guys sapping people's gut biome as well as to see how that impacts me? Because obviously, that's DNA is foreign to us. But it's a lot of impact. But the interesting thing, one thing I will say about my microbiome is finally where you look at what was recognizable single world intestine and they're people they don't hit what they collect in this. They look at microbiome and say, in fact, at least what we consider that microbiome is a lot in the small intestine will fairly sterile and they'll do this exception to this. Some of them have it. I'll do you guys incorporate the microbiome into this algorithm. All that presiduous machine is key in implementing our new DNA got 360, which has been, it has been so accepted by our community because of the power of it to a persistent. Yeah, I think that I've been playing in practicing with James for about six years now. And I found my first one in the space. My first video is that it's just focused on the gene books. Translate to people to talk to stats. Great. How do we take the data and those shifts their clinical then? But people who come back and say, we want more of this hair, we want this sort of further clinical data because we know it's not just genes. I can't even think of a sudden lifestyle and only 20% genes. We know that there has to be complement between the two. And so I think to me, the genes and the blueprints there are set at the stage. They say, are you someone from a matter of perspective that does well with fat and carbohydrates and coaching and what combination they're of? And then this sort of biome testing, the follow-up testing further refines that because you know, for example, within the biome, certain biomes will shift how you're metabolizing, right? They'll increase or decrease metabolism, capacity to gain weight or not. Knowing where a person's biome will further guide and further flush out what they're like and how their body is responding to that, right? I think it's not all diets are created equal, right? Different quips in your life based on your biome and based hormones, it's already juiced, you're going to respond to it. And so we select a lot of our biomes in the nation based on how do you use it, right? So in the middle you go out to different families. We don't go and like are nuanced into the sense of this one strain that was studied means this is we only focus on that strain. We look at a lot of family, we look at families that reflect how is that permeability? How happy is everything there? And then separate to that, how is it impacting metabolism? Because by and large, the shovels influence the longevity, and separately, we're all vain creatures, we all care about what we look like, and it influences that as well. So you tend to go up with some and those sorts of and measures that permeability, that health, intestinal lining health, and then separately, how it's bubbly and impacting immune and health. I've seen this way, I can directly call it, I've had patients, but there's like Ehlers-Danlos Syndrome, which is, it's a genetic collagen disorder. It's, I've seen their club present presentation dramatically, to go up to essentially asymptomatic, where they will dislocate in joints every day, like we did the whole shoulder dislocated, the knee dislocated, so like that. And changing the vibe, taking their genetic, what I believe is, well I know it's a genetic disease, and it backen it to such such a reason. How much do you think these lifestyle impacts, you said genetics, born of yourself, and it's a cancer, infection, born of health, how impactful can we impact what are, because we have to be like, I'm blue-eyed, I'm tall, I'm around here, that's, you're not, I could tie my hair in the context of all this, but maybe realistically, I'm where I am, but how much of me is changeable through diet and lifestyle, where I come to the disease, actually I didn't put on my swan, meaning that you have your good, how much of that genetic presentation, spent in my seat at diabetes, or Alzheimer's disease, what are we things that have to do in this position, can we change? Yeah, so there's a, we look at orchard with the genome Tengalyi P2-1, and this was first on Earth about 15 years ago, and it was highly correlated with the incidence of cardiovascular incidence, so either stroke or heart. And we found that we looked at three attempts, and we found that people with, between those three steps, the greater presentation of the certain allele, out of greater likelihood, towards these cardiovascular events. So there's this elimination, there's a gene, but to an extent, at least at the time, destined you to warrant the cardiovascular event. Now that we've had some time in space between us realizing that and intervention, to me, what I've seen over those 15 years in the research is we can't change that presentation, if you have that, and see those pyrophypancies of gene alleles, there's a greater likelihood period of cardiovascular incidence, but now that you know that, especially the younger you know that, the more you could intervene with theory of focused and diet and lifestyle interventions. So for a second, and to your point, this is to an extent like some of the time you can look at your hundred and finding, right? We now know sure as that possible, but how is what we're unearthing right now? And so I think, what are the awareness of NIPA-2-1, this cardiovascular incidence, right, coupled with another genetic relation? We can't guarantee that this is going to avoid cardiovascular event, but we have such exacting precision into other elements that commute and attenuate that, that that is our best effort towards mellifying that and reducing that risk. If that gets you out of your hand, that higher presentation, that greater likelihood towards storkan inflammation, the underlying mechanism there is cardiovascular inflammation, right? At that first layer of cells, and every ounce of the vascular secure system, that interface, goes with a certain presentation of a population. Okay, knowing that, what can we do about that? Just estimate a lot of things, we look at as an methylation, we know that methylation curates hormones, it curates detox, it curates brain chemistry, it curates several things, it curates cell turnover. So let's ensure that system is clean, you've got one of these, that's one thing you can do to prevent them, right? We can look at other cardiovascular genes, we can look at genes that are blood pressure, blood movements, other things of that, let's optimize about against that, right? Another check mark, we can look at her point celiac or other fields that will impact the gut and further burn in inflammation, right? So none of this is to say I can completely attenuate mute 9P2 land, but with the awareness of I have this gene that predisposes to, or the other dinner syndrome that you just mentioned, you can't change that, right? Sure, of course, burn when I hit that point, you can't change that, but you can take into account every other monofileable aspect and personalize and tell it based on what your body's defense is on, right? And it also tells you too, I'm a huge believer in lazy has a negative connotation, I think lazy restful lesson, let's do things as optimal as possible. So we feel you already have, for example, a beautiful methylation use, let's not focus on that unless there's something that says we need to instead let's focus on the genetic weaknesses, so that we're investing our energy and effort optimal. Does that make sense as an answer? Yeah, to a degree. So let me just, how somebody comes to you, the simple genetic details, Mike, that's in blood and prevention on that, you have a prescription isolate and some sort of action plan, and then how does that evolve from there? Believe me, they try this for a while and they say, obviously, they've got a goal, I'll try to get you to do something. I don't know how you measure progress. And for that, it depends on what wisdom is forward with, right? If it's if they're post-MI, there's already a suite of blood working that can support kind of monitoring of that. I think if it's morally a theory or goal by want to be well, in general, we do have some technology that looks at epigenetic methylation patterns. And so a lot of these patterns have been studied to show how stressed is your DNA, right? And what I mean is stressed, certainly methylation patterns are taught DNA, express that a person is gone through a lot and the DNA is not presenting optimal, right? It's showing the signs and symptoms of aging. And so we can leverage testing like that, we take it day one, right? We produce some sort of intervention plan curated based on other genes and other diet of stealth factors. And then six to 12 months later, new science theories while it's acting, we can take another sample. Now I'll show how is the stress at the top of their DNA? Is there less stress in general, most of in the model, how those epigenetic patterns, post-methylation patterns change? That's one of the more of a theory way, but again, if it's if there's a more specific clinical complaint, and it depends on the complaint and that we can leverage different meters, sorry, and I would say a practical aspect, you get a very extensive report that says, hey, you need restaurant car risk support, here are the ways you can do that. Now a lot of people do DYI, they're already healthy, maybe they're already keto, they're a carnivore, but they just shake it with last two pounds up, then they sign out that, oh, maybe they're estrogen dominant, and they need to look at their hormone component, oh, they may also not process fat as well as they thought they did, so maybe they need to look at, oh, I'm adding a bunch of coconut oil or I'm adding too much avocado oil on top of my meat, maybe I'm eating lean chicken or not as fatty of a fish, maybe I need to switch to fatty fish, maybe I need to stick to Revi right now, they're able to use that. We also have coaching programs where people can work with function genomic gestures, we also have NDs, MDs, fernDs that can go through, I get a lot of people, women primarily, that have hormone things, if I can't lose that last 10 pounds, so we will look at their hormones, do they need to be on bioidenticals, do they have a genetic pattern that they need to pull some things out of their diet or add some things to their diet, do they need to move differently, so we can coach them through that, we have people who have failed with five, 10, 20 physicians, and we have a precision program where we follow them for a year and in touch with them of multiple practitioners, back to the old school, team approach of everybody supporting in their area of specialties, we have lots of ways to support people based on their needs, but I think the biggest thing is that people can now have action, this is where I'm starting, that I'm frustrated, this is the goal where I'm going, and we monitor them a long way till they say, yes, I am feeling less stressed, yes, I have lots of inflammation, yes, I have lost those 10 pounds, so there are always actionable key indicators so that they go, oh, it's not just that theoretical, it is, I was able to finally fix what I had made a little fix in the past. When you, so if you take an initial genetic analysis, so you know, obviously, the actual, one of the nucleotides there, yeah, the sense that we'll start off from the end of the genetic level, and you can re-in check that again, in how much difference can you see between one, one more year and another year instead of 10 year one, how much do you typically see? I'm just wondering how impactful that is. Yeah, so through epigenetic testing, two primary measures, there's a few more, but two primary measures is going to be, how quickly, biologically, the work agent can capture a lot of here. For example, a calendar year passes, the question is, does your body think it's just been a year, does it think it's been less, i.e., you're slowing, you're aging slower than the walk, or does it think it's been more than a calendar year, you're aging quicker than. So when we think of epigenetic aging, we bring it back to human terms, and so I've seen some people in particularly, and this is, I want to acknowledge these are the people who started off in the rough way, and then truly implemented change, so I found the change that they implemented, but I've seen some people like shave 10 years off the weight that which they're aging, right, just and again, this is an incredible overhaul, I would say it's an exceptional that over the course of the year you're seeing someone shave 10 years off the biologic age, but it is things like that, I've seen people who are aging faster than the clock, markedly slow that down to the point where their body is now experiencing one calendar year, is if it's only maybe thin and it eats a year, they're aging slower than one week. And I think also separate in a part from that, I think with medicine, it's very tempting to get lost within eights, empirical and chasing data, and forgetting to check in with the clients as well as how are you feeling, because there's many times where I haven't seen per se lab measures change, but the person is, I feel so much better in the way my body experiences life, I don't care if the lab measures have not changed, I'm going to continue this for another reason, then it's bringing joy and peace to the way I'm living to my health, right, it's that concept of we don't necessarily want life and we don't love those 120 years, if they're going to be 120 years in pain, we want that health stand, those 100 years of healthy, actionable years, because they would offer an additional two careful evidence, we need to look at them and it's a little more intangible and not experienced, right, because that's two degree why people are chasing health, is very few that siblings that simply just took me to find a way to talk about genetic clocks or methylation clocks, tell them a lot, if I don't have any other things of them, you utilize to postulate the purpose of age and refs. When it comes to human data, I just wonder how you validate it, because I can see animals, when you're going to handle those three years, momly, you can assess that, but how are we able to say this is actually extrapolated, like two humans, and we both have 120 year data that we can look at, how do you say this is that got it? Yeah, yeah, I acknowledge and borrow this a little bit in the sense that I'm not a cognitive research director, I do not really focus on this, but my understanding that at least the companies that we engage with can make, we employ science that has been validated by the Harvard's and local human clinics of the world, and a lot of this is done initially, yes, through some animal models, but it is in large part due to bioinformatics and computing capacity, right, so it's the ability to take these measures and then compare them in a large population scale. Some of the smaller sales studies that are now happening are more where they take that restructure at eight o'clock, there is an implementation of change and they're doing it again, as well as comparing that with peer research and these large bioinformatics libraries, small scale studies that we'll do before and after measures, but fueled further by large bioinformatics libraries, where you're able to get extrapolate information from this, simply because the struggles the kids owe up to date, and they're all like I suffer though, and they're the ability to compute large operation and just getting better. Yeah, when we started, we did initial studies with live humans, and we had 7,000 participants using the actionable genes going point A to point B, so unlike a lot of companies that only do computer models, or they only put out interesting, I think for us, that do for you from charity, we had 7,000 bodies that we did before an endpoint and can see actionable differences. Now, that was over a short period of time, but as they continued that, we can continue to monitor, which is why we continue to add SNPs and as Chris was just mentioning, we're about ready to release another, I think it's like 10 or 13, and then after the first of the year, we'll look to 100. All of our clients did that updated report. There isn't a well for 29.99 you get to come and find out the new data. We're going to give them that actionable. We want them to continue to roll, and as such, we have a very engaged community that comes back again and again to gather more data. So when I look at some of the other standard offers of aging, what got lots of scalable maps, we go into them, we look at decreasing VO2 max, and there's a lot of things that we know directly quality range, and so can we compare those metrics? I don't know if this is despite it, while I still keep talking about all of these. If I were a CT scan, and I knew all of us, there's a 20 goal. I'm at my camera, and a lot of people's needs, and it was all two different departments. I'd say that's it. That knee looks like it's been around the block, and that knee looks fresh and clean. Do we have any core relative data? Because obviously, we don't have a lot of study of payments that would be more suited for. I mean, over a five-year period of time, you can see, oh, maybe a decade. You can see, hey, this person's being seen last decrease, one or two percent of the other being expected to leave. Can we look at any of that information? Yeah, and I'm speaking right now at least. So when Dr. Seth was talking about that, a thousand testing, that's looking at DNA from that SNF level. And so has that data been trained there? No, but we can monitor that over time. These changes from an atly genetic perspective, right? That, right? But aging has one metric and one insight into aging. Part of the validation of that, right, in the fore and after that larger population day of study, right, is can these models, can the methylation patterns predict where person is age-rate relative to VO2 max, relative to not EMI, but a few other more quick measurements, right? So it's trained and validated against models like that. Yes is the answer. We have not done that prior research ourselves, but we leverage certain algorithms done deep case, and few other aging algorithms, they're all validated against that information. Yeah, I see more and more various models of aging based on blood pressure. And so I can't help it, but sometimes when one is that one in clinical action, because it really clinical act for the action, well, to me, it's quite a run fast. That's pretty neat. There's a lot of cognitive disorder in my view. But what about if we look at, like, how much could someone, obviously, if someone is just pouring or smoking all the way for their exercise and stay up all out and work the night, check, and put that motion anywhere healthy, you're going to see it in full looks. But the average person, it maybe has an average lifestyle. I'm just going to expect that to maybe look at something for me. He's eating clock, she might want to let's go. I want to add an anecdote, which is just my personal story. I was in a car accident, and they did an MRI on my back. And I had desiccated discs at L4L5 and L3L4, they were torn. They were like, "Oh my God, these are never coming back, eating back surgery." And I'm like, "I'm not ready for that yet." I then got the data on how to process fat and what my body worked and didn't work and put that in. And four years later, I had another catch from my back and I went in and had another MRI. Those desiccated discs had re-ballooned. So, they'll raise into a great all of the, I had that collagen and was doing more of a keto-type last time, I'm sorry, carnivore. But they had healed, I did not have any problems in the areas where they had said, "This can't be your back." And because get dust don't come desiccated and then rehydrate. But between the actionable steps that I knew, even though I had another thing, I ended up having a small amount of calcification, which was able to be taken care of. But it was, we had been seeing a completely different presentation clinically with, they were just blown away. Like, oh, that body, this thing that we call our body, cham or care, when it's put in the optimal environment, it knew what to do. But I didn't have the data before. I have the data now. I utilized it and everything shifted. So, I can tell you that we may not have it as a company and we may not do that individually with everybody. There are people that go, I've tried 20 years and this was the first time I've actually been able to remove the needle. And we have hundreds of those stories of people that finally have one or two genes that they just didn't understand and now they do. And a lot of it has to do with restaurant covering. People, we are just such an alpha-driven go, everything has to be extreme. And they realized that they got a rest, they got a repair and how do they get off their phone to go to bed early and nutritionally supplement or what diet is more optimal to them so it puts the body in the environment where it can feel. Yeah, I'll get asked you the biggest leverage you can pull for going to these things. They actually get your personal experience, which you know you've got, I assume some work in the engines that follow up on basis. So, visit diet, visit sleep, visit exercise or do some other things that are equally as important when you want, when you're upbeat. It ends up being a whole tongue matter. You've got to have the right food, the right movement, the right environment, stress and all, the right recovery. It's not a single agent, but yes, we have ones again that are customized for each person's genetic profile. And so, can we see trends? Yes, we can see trends. I can tell you that I ate what I'd call the vegetarian diet, which was actually a gluten diet, dairy diet and sugar diet. Develop cancer at 21. I was going to have a bone marrow transplant because it couldn't figure out how to reset my immune system. I ended up not wanting to spend a million dollars in medical debt and went to a very strict paleo. It was eggs and spinach for breakfast. It was chicken and lettuce for lunch. It was beef and broccoli for two years. That feel the majority of mine. I played with paleo. I played with Mediterranean. I played with keto. None of those really, that paleo was the best but I still have my sugar cravings. I only have five pounds more than I did when I graduated from high school. But after you and I met in Austin, then I thought I'm really going to play with this part of our thing and see. And the full thing that has been pulling some of those vegetables now and that thing that I was a big fish eater now, I'm doing fatty fishes less often. My family brew or raised cattle, I've always been a beef fan but I'm really eating the fat. I wasn't, I used to trim it all off. So in the last month, name of this, I've watched all of my sugar cravings go away. I've watched all of my things, tweaking people that are stuck at places even though they're doing Mediterranean, even though they're doing. It's giving me new ideas on how to loop the needle even further for them. And I do think there's a lot of validation for what the carnivore community is doing. And I love that there's variety between that, the reconnaissance district. It's not just beef butter, bacon, and salt water. There, there are flexibility. You can embrace to have a special occasion but I can tell you, I asked a little various the other day with the scooter egg platter and I instantly went into eye lot dessert where I had it for two weeks, not even thought about dessert. So it's time to be able to move people's needles with how they move, how they sleep, how they stop the limit because we can't get everything in some people's cases without some sort of a tradition, especially detox when they have their GSTT and they don't detox well. We can use some herbs and things to help them detox, which will help their recovery much faster and maybe it's a short-term thing or maybe it's a long-term thing. But the looking for stuff that isn't full of junk and is a full of lactose and helping point them toward those type of things really is rewarding when they finally get those aha moments. Guys, maybe sorry, we are, unfortunately I'm on a time in this quantity. And you got share of what side of the nation, social media, whatever people would have an interest in this work and apply them in today. Sure, it's the DNA Company.com and Dr. Baker, you've been so gracious to have us. We want to offer a discount. If people want to get their DNA done, we're going to offer $50 off. If they go on to our website, the DNA Company.com and order of test, if they put in the code, Sean Baker, then they will get $50 off their chest. And we also, in a send-out copy of the DNA Way, which goes through all what our founder did to repair himself, repair his family, a lot of the research as well as a lot of the understanding so that they can take their DNA and really run with it and have a better life. So we still appreciate the opportunity to be here. We still appreciate what we're doing to help heal the world. And we just, we want to help share that and help people find that little extra edge. Yeah, that's your name. So it's the DNA Company.com, correct? Make me use code, Sean, that it serves for the cookie box. Yeah. Awesome guys. Thank you very much. After that, we'll just offer a little bit some interesting discussion and it says that we'll be able to work again. Thanks so much.
