Článek Simony Procházkové. Leidenská mutace, často označovaná jako faktor V Leiden, byla poprvé objevená v roce 1994 ve městě Leiden v Nizozemsku (odtud také její název). Jde o genovou mutaci, která zapříčiňuje zvýšenou srážlivost krve, což může vést k nejrůznějším zdravotním komplikacím, od samovolných potratů až po plicní embolii.
„Leidenská mutace je mutace v genu pro faktor V koagulační kaskády, což je proces, který kontroluje srážení krve. Její přítomnost vede ke zvýšené srážlivosti krve a výskytu s tím spojených komplikací. Jedná se o nejčastější vrozenou trombofilii (zvýšenou krevní srážlivost), která postihuje asi 5 % evropské populace. Tyto osoby jsou ohrožené především trombózou a plicní embolií,“ popisuje lékařka Eva Šťastná z kliniky IVF Cube.
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